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Table 3 Values of the performance measures for each aspect of validation of the original KFRE

From: Using the kidney failure risk equation to predict end-stage kidney disease in CKD patients of South Asian ethnicity: an external validation study

Performance measure

White cohort (95% CI)

South Asian cohort (95% CI)

Discrimination

 C-index (up to 5 years)

0.908 (0.887, 0.930)

0.954 (0.937, 0.971)

Calibration

 O/E ratio

0.623 (0.505, 0.740)

0.979 (0.789, 1.169)

 Calibration intercept

–0.394 (–0.555, –0.232)

0.107 (–0.159, 0.373)

 Calibration slope

1.05 (0.920, 1.18)

0.843 (0.690, 0.995)

Overall fit

 Brier score

0.011 (0.010, 0.012)

0.029 (0.022, 0.035)

 Scaled brier score (%)

24.6 (16.6, 31.1)

34.7 (20.7, 45.4)

  1. The 95% confidence intervals for the c-index and scaled brier score were calculated via bootstrapping with 1000 samples. CI Confidence interval, O/E ratio observed/expected ratio
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Diagnostic and Prognostic Research

ISSN: 2397-7523

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