Table 1 Descriptive statistics for each of the ten trials after multiple imputation
Trial | Bucher | De Sutter | Kaiser | Meltzer | Merenstein | Schering-Plough | Stalman | Varonen | Williamson1 | Williamson2 |
|---|---|---|---|---|---|---|---|---|---|---|
Number of participants | 251 | 368 | 266 | 490 | 135 | 458 | 191 | 150 | 116 | 114 |
Antibiotic assignment (%) | 49 | 49 | 51 | 50 | 50 | 48 | 51 | 59 | 51 | 45 |
Female (%) | 54 | 57 | 52 | 66 | 69 | 70 | 64 | 70 | 72 | 76 |
Age in years, mean (SD) | 36.6 (13.1) | 38.4 (14.2) | 32.8 (11.6) | 35.7 (12.2) | 33.9 (9.8) | 38.7 (14.6) | 37.0 (11.4) | 39.7 (13.4) | 43.3 (15.5) | 43.8 (12.7) |
Preceding URTI (%) | 56 | 79 | 35 | 78 | 52 | 76 | 92 | 56 | 71 | 67 |
Symptom duration in days median (IQR) | 4 (3,7) | 6 (3,10) | 4 (3,7) | 13 (10,19) | 9 (7-14) | 13 (10,19) | 7 (6,14) | 5 (3,9) | 5 (3,10) | 5 (3,7) |
Pain on bending (%) | 82 | 69 | 27 | 86 | 81 | 85 | 90 | 78 | 82 | 85 |
Pain in teeth (%) | 24 | 44 | 14 | 85 | 28 | 81 | 50 | 19 | 37 | 56 |
Unilateral facial pain (%) | 54 | 55 | 14 | 98 | 39 | 98 | 42 | 23 | 52 | 51 |
PNDsr (%) | 98 | 88 | 51 | 67 | 84 | 53 | 83 | 48 | 74 | 67 |
Symptom severity, | 44.2 | 50.6 | 46.0 | 41.8 | 43.7 | 48.5 | 48.1 | 55.7 | 56.2 | 48.5 |
median (IQR) | (19.8, 67.8) | (24.4, 62.7) | (15.8, 74.1) | (23.4, 79.6) | (27.0, 78.6) | (28.4, 77.5) | (23.1, 74.7) | (25.7, 76.0) | (27.7, 82.1) | (27.7, 73.1) |
Fever (%) | 14 | 7 | 11 | 1 | 1 | 2 | 4 | 18 | 3 | 4 |
PNDex (%) | 66 | 55 | 33 | 33 | 32 | 31 | 12 | 32 | 39 | 31 |
PPDex (%) | 21 | 45 | 18 | 45 | 55 | 34 | 9 | 72 | 22 | 25 |
Cure (%) | 69 | 35 | 56 | 69 | 49 | 66 | 65 | 77 | 64 | 65 |