Potential prognostic factor | Unadjusted OR (95%CI) | Adjusted* OR (95%CI) | p value | Change in c-statistic†|
---|---|---|---|---|
Fetal adverse outcome composite | ||||
 NT (% discordance) | 1.03 (1.01, 1.05) | 1.03 (1.01, 1.06) | 0.011 | 0.045 |
 CRL (% discordance) | 1.16 (1.06, 1.27) | 1.17 (1.07, 1.29) | 0.001 | 0.103 |
 AFP | 1.91 (0.93, 3.94) | 2.08 (0.94, 4.59) | 0.071 | 0.026 |
 sFlt-1 | 1.12 (0.52, 2.40) | 1.03 (0.42, 2.50) | 0.950 | < 0.001 |
 PlGF | 0.73 (0.44, 1.22) | 0.65 (0.37, 1.13) | 0.125 | 0.014 |
Twin-twin transfusion syndrome (TTTS) | ||||
 NT (% discordance) | 1.05 (1.02, 1.08) | 1.06 (1.03, 1.10) | < 0.001 | 0.137 |
 CRL (% discordance) | 1.07 (0.96, 1.20) | 1.09 (0.97, 1.23) | 0.161 | 0.032 |
 AFP | 3.04 (1.05, 8.78) | 3.24 (1.00, 10.48) | 0.050 | 0.067 |
 sFlt-1 | 1.91 (0.62, 5.88) | 1.64 (0.44, 6.03) | 0.459 | 0.006 |
 PlGF | 0.43 (0.20, 0.91) | 0.42 (0.19, 0.93) | 0.032 | 0.074 |
Antenatal growth restriction | ||||
 NT (% discordance) | 1.01 (0.99, 1.03) | 1.01 (0.99, 1.04) | 0.261 | 0.014 |
 CRL (% discordance) | 1.17 (1.06, 1.30) | 1.20 (1.08, 1.34) | 0.001 | 0.119 |
 AFP | 1.55 (0.67, 3.55) | 2.10 (0.82, 5.40) | 0.123 | 0.032 |
 sFlt-1 | 1.25 (0.50, 3.13) | 1.47 (0.49, 4.35) | 0.491 | 0.011 |
 PlGF | 0.91 (0.50, 1.66) | 0.88 (0.44, 1.76) | 0.720 | −0.001 |
Single intrauterine fetal death (sIUFD) | ||||
 NT (% discordance) | 1.01 (0.98, 1.05) | 1.02 (0.98, 1.06) | 0.425 | <−0.001 |
 CRL (% discordance) | 1.17 (1.00, 1.36) | 1.19 (1.01, 1.40) | 0.035 | 0.085 |
 AFP | 0.68 (0.16, 2.87) | 0.80 (0.17, 3.90) | 0.787 | −0.004 |
 sFlt-1 | 1.27 (0.27, 6.04) | 1.79 (0.30, 10.64) | 0.523 | <−0.001 |
 PlGF | 0.35 (0.13, 0.97) | 0.34 (0.12, 0.98) | 0.045 | 0.057 |
Double intrauterine fetal death (dIUFD) | ||||
NT (% discordance) | 1.02 (0.98, 1.06) | 1.02 (0.98, 1.06) | 0.420 | −0.005 |
 CRL (% discordance) | 1.06 (0.91, 1.24) | 1.12 (0.94, 1.33) | 0.221 | 0.019 |
 AFP | 1.33 (0.34, 5.21) | 0.97 (0.18, 5.33) | 0.970 | <−0.001 |
 sFlt-1 | 4.13 (0.92, 18.58) | 8.21 (1.02, 66.24) | 0.048 | 0.035 |
 PlGF | 0.23 (0.08, 0.63) | 0.18 (0.05, 0.58) | 0.005 | 0.080 |